Research and Grants

Impact Study of Meningococcal Conjugate Vaccination

The impact of meningococcal conjugate vaccination on pharyngeal carriage of serogroup A meningococci and on transmission of the infection. PI: Brian Greenwood Funders: Wellcome trust and BMGF. The African Meningococcal Carriage Consortium (MenAfriCar) was established in 2009 to determine the pattern of meningococcal carriage across the African meningitis belt before and after the introduction of […]

Trials of New Pneumococcal Vaccines in Gambian Children and Infants

PI: Aderonke Odutola (MRC Unit, The Gambia) Funders: PATH This study is investigating whether addition of two proteins found in all pneumococci (pneumolysin and histidine triad protein)  to the 10-valent pneumococcal conjugate vaccine produced by GlaxoSmithKline (PCV10) can increase the ability of this vaccine to provide protection against pneumococci of serotypes not represented in the vaccine. […]

Pneumococcal Conjugate Vaccine Trial

A phase IV effectiveness study of pneumococcal conjugate vaccine in The Gambia. PI: Grant Mackenzie (MRC Unit, The Gambia) Funding: GAVI, BMGF Following the conduct of a successful trial of a nine-valent pneumococcal conjugate vaccine (PCV) in Upper River region, the Gambian Ministry of Health introduced a seven-valent  pneumococcal conjugate vaccine (PCV7) into the routine […]

Malaria Vaccine Trial

Efficacy of GSK Biologicals’ candidate malaria vaccine (257049)(RTS,S/AS01) against malaria disease caused by P. falciparum in infants and children in Africa. PI: RTS,S Clinical trials partnership (there are no PIs)(LSHTM investigators include Chandramohan Drakeley,  Greenwood, Riley and Schellenberg) Funding: PATH, GSK This phase three trial is being conducted in 11 centres in 7 countries in […]

Typhoid Vaccination in Fiji

PI – Conall Watson Funder – MRC, WHO Western Pacific Region, The Chadwick Trust Indigenous iTaukei Fijians are experiencing a typhoid fever outbreak that began in the mid-2000s, largely affecting young adults in rural areas. LSHTM and partners at the World Health Organization, Australian Aid and international universities are supporting the Ministry of Health to […]

Potential Impact of Future Tuberculosis Vaccines in Setting with High HIV Prevalence and in Aging Populations

PI: Rebecca Harris Funding: MRC and Aeras This research will use models to estimate the epidemiological impact of promising new TB vaccines in high burden settings, with the aim of informing which vaccine candidates and vaccination populations could deliver the greatest public health impact. This will include modelling vaccine impact in settings with high HIV prevalence experiencing […]

WHO Initiative for Vaccine Research/Global Malaria Programme Joint Technical Expert Group

Peter Smith chairs the WHO Initiative for Vaccine Research/Global Malaria programme Joint Technical Expert Group (JTEG) on Malaria Vaccines Entering Pivotal Phase 3 Trials & Beyond which was established in April 2009. JTEG provides advice to WHO on activities related to the development of malaria vaccines at or nearing the pivotal phase 3 trial stage. Stefan […]

Natural Killer cells as effectors of vaccine-induced immunity

PI – Professor Eleanor Riley Funder- Medical Research Council The purpose of this research programme is to evaluate the predictive potential of two new potential correlates of protection (the identification of immune responses which, when present, are a good indicator that the person is protected), namely the ability of immune cells called T cells and NK […]

The Vaccine Confidence Project

Monitoring public confidence in immunisation programmes PI: Heidi Larson Funding: Innovative Medicines Initiative (IMI), National Institute for Health Research, the World Health Organization, the Bill & Melinda Gates Foundation, Novartis, Center for Strategic & International Studies (CSIS), Pharmaceutical Research and Manufacturers of America (PhRMA). Partners: Public Health England, HealthMap, ProMED, Imperial College London, Brighton collaboration, Chatham House, The Inclen […]

PATH SPN Whole Cell Vaccine

Funding: PATH Vaccine Solutions Anthony Scott works with the Clinical Development team (Scientific Lead: Dr Cheryl Keech) at PATH, Seattle, to advance a third-generation pneumococcal vaccine. The cost of developing and manufacturing pneumococcal conjugate vaccines (PCV), and the limited serotype coverage of current PCVs suggests the need for a vaccine that is effective against the […]

Pneumococcal Conjugate Vaccine Impact Study

PI: Anthony Scott Funding: Wellcome Trust and GAVI Alliance Using a passive-surveillance system established in 2003 at the Kilifi Health and Demographic Surveillance System, in Kilifi, Kenya, this project is a Phase IV, before-after study, examining the population impact of the 10-valent Pneumococcal Conjugate Vaccine (PCV), which was introduced into the Kenyan childhood immunization system […]

The NIHR Health Protection Research Unit in Immunisation at LSHTM

The NIHR Health Protection Research Unit in Immunisation at LSHTM PI: Anthony Scott (LSHTM) and Mary Ramsay (PHE) Funding: National Institute for Health Research This is one of 13 Health Protection Research Units (HPRU) funded by NIHR to foster collaboration between English Universities and Public Health England. The 5-year project aims to undertake research to […]

Workshop of Evaluation of Vaccine for Public Health

PI: Laura Rodrigues and Eliseu Waldman Funder: FAPESP (submitted for funding) A 3 day workshop for early career scientists between LSHTM and other UK institutions and USP and other Brazilian institutions to share research experiences and explore collaborations.

Evaluation of an E-health Vaccine System: The Juarez System in the City of Araraquara, Brazil

PI: Ana Paula Sato; Co-PIs: Eliseu Waldman, Laura Cunha Rodrigues and Edmar Martineli Funder: FAPESP (submitted) Introduction: Electronic systems with information about vaccinations with individual records are in the process of being developed in Brazil as tools for scheduling vaccinations, recall and monitoring of vaccination coverage as well as a research tool. Objectives: To evaluate […]

Pertussis Vaccination During Pregency and Reduction in Incidence in Children Under 1 in Brazil

PI: Paulo Batista Funder: CNPq –Brazil Petussis vaccine was introduced to pregnant women in 2013 to prevent pertussis in children to you young  to have received compete vaccination and to contribute to the reduction  the incidence in infants in general.. This project  evaluates the efficacy of vaccination by comparing incidence of pertussis in children born to vaccinated […]

Rotavirus Vaccine

PI: Mauricio BArreto,ISC, Brazil and Yuri Travassos, PhD student Funded: Brazilian MRC A case control study of rotavirus vaccine efficacy, conducted in 4 regions in Brazil, where cases are hospitalized cases of diarrhoea with confirmed rota is stools and controls are children hospitalized with for other non vaccine related conditions; diarrhoea without rotavirus were also ascertained to […]

BCG Revaccination Trial

PI : Laura Cunha Rodrigues and Mauricio Barreto Funders: DFID, Brazilian Minister of Health A cluster-randomized trial involving more than 200 000 school-aged children from Salvador and Manaus (BCG-REVACC) followed for over 20 years. The trial tested BCG-VE of a second BCG dose against tuberculosis and against leprosy when administered at school age. The trial […]

Observational Study to Estimate the Changes in the Efficacy of BCG with Time Since Vaccination

PI: Laura Rodrigues, Punam Mangtani, Ibrahim Abubakar Funder: NIHR BCG vaccination until 2005, was given mostly at school children; since then it is given to infants if required. We know that BCG is a relatively good vaccination when given at school-age, but we do not know the exact protection. We do not know if any […]

Production of Inexpensive Recombinant Glycoconjugate Vaccines

PI – Professor Brendan Wren 
Funders- Medical Research Council, Biotechnology and Biological Sciences Research Council, Defence Science and Technology Laboratory, The Gates Foundation The most successful human vaccines are often glycoconjugate as the combination of a protein coupled to a glycan induces both a T-cell dependent and independent immune response evoking a protective and lasting […]

ProVac Initiative

Support for national policy choices about new vaccines in low and middle income countries PI: Andy Clark Funding: BMGF (via PAHO) ProVac (promotion of evidence-based decision making for the introduction of new vaccines)started as an initiative in the Americas region of WHO to strengthen national capacity to conduct economic evaluations of new vaccines. An important part […]

Vaccine Schedules Initiative

Support for global and national policy choices about vaccine schedules in low and middle income countries. PI: Colin Sanderson Funding: BMGF (via WHO) The WHO Initiative for Vaccine Research (IVR) has commissioned researchers from the Vaccine Centre (Andy Clark and Colin Sanderson) to evaluate the balance between benefit and risk for rotavirus vaccination, and the impact […]

Supporting cost-effectiveness evaluations of human papillomavirus in low and middle income countries

PI: Mark Jit Funding: WHO WHO recommends that cost-effectiveness is considered before human papillomavirus (HPV) vaccination is introduced into national schedules. However, resources for cost-effectiveness evaluations are often limited in many low and middle income countries. This project aims to understand current cost-effectiveness evidence behind HPV vaccination options in such countries, to compare existing economic […]

Assessing the broader economic impact of vaccines and immunisation programmes

PI: Mark Jit Funding: WHO Economic evaluations of immunisation programmes usually focus on the morbidity and mortality prevented by the vaccine together with its economic impact on the health care sector. More recently, greater attention has been paid to the economic impact of vaccines on broader measures, such as cognitive and educational outcomes, household decision-making, […]

Evaluating the health and economic impact of a risk group based strategy for seasonal influenza in low and middle income countries (LMICs)

PI: Mark Jit Funding: WHO The World Health Organization’s expert committee on vaccination (SAGE) has recommended introducing seasonal influenza vaccination for pregnant women, then for health care workers, people in clinical risk groups, the elderly and children. However, economic evidence to support such introduction decisions is scarce in low and middle income countries. This project […]

Costs of introducing pneumococcal, rotavirus and a second dose of measles vaccine into the Zambian routine immunisation schedule: Are expansions sustainable?

PI: Ulla Griffiths Funding: Bill and Melinda Gates Foundation through Center for Infectious Disease Research in Zambia (CIDRZ) Introductions of new vaccines in low-income countries have accelerated since the GAVI Alliance was established in 2000. In this study the economic costs and the sustainability of introducing pneumococcal conjugate vaccine (PCV), rotavirus vaccine and a second […]

Evaluation of costs and performance of meningitis surveillance in Chad

PI: Ulla Griffiths Funding: Bill and Melinda Gates Foundation through Agence de Médecine Préventive Chad, like other countries in the African meningitis-belt region, has historically been ravaged by recurring meningitis outbreaks, mainly caused by serogroup A Neisseria (NmA).  A new conjugate vaccine (MenAfriVac®) developed to combat this strain has shown to be effective in decreasing […]