News

Scientific Meeting

Estimating the impact of a maternal RSV vaccine using a mathematical modelling approach   By Alexandra Hogan   Abstract   Respiratory syncytial virus (RSV) is an important respiratory pathogen in children and presents a significant global health burden. It is the main cause of hospitalisations in young children. There is currently no licensed vaccine for […]

Scientific Meeting

Manson Theatre, Keppel Street   12.30   ‘Vaccine induced T cell protection against respiratory infections’   Presented by: Dr John Tregoning Group of Mucosal infection and Immunity Faculty of Medicine Imperial College London   13.00   “Natural and vaccine-induced cellular immune correlates of protection against influenza”   Presented by: Professor Ajit Lalvani Chair of Infectious Diseases, Director, […]

“Safe and efficient implementation of Dengvaxia – tackling remaining challenges”

    Wellcome Trust, 183 Euston Rd, Bloomsbury, London NW1 2BE The World Health Organisation’s Strategic Advisory Group of Experts on Immunisation recommended in July 2016 that countries should consider introduction of dengue vaccine only in national or subnational settings with a high burden of disease and to target age groups where more than 70% […]

Vaccine Confidence Project “Building Trust, Managing Risk: Vaccine Confidence and Human Papillomavirus Vaccination” Symposium

The Vaccine Confidence Project and the HPV Prevention and Control Board are pleased to invite you to their upcoming symposium. Symposium sessions will cover topics related to: The state of HPV vaccination in the world HPV vaccination: real and perceived safety issues Culture, religion and morality around HPV vaccination Immunization anxiety reactions and the HPV […]

Scientific Meeting

Scientific Meeting Friday 17th March 12.30-13.30 Manson Theatre, Keppel Street Anthony Scott, Chair    12.30  Assessing the efficiency of catch-up campaigns for introduction of pneumococcal conjugate vaccine; a modelling study based on data from Kilifi, Kenya Presented by: Stefan Flasche, LSHTM   13.00  HPV vaccination operational scale up and catch up campaigns in Africa Presented by:        Helen Rees, […]

Meeting: Vaccine evaluation, implementation and policy

Vaccine evaluation, implementation and policy Date: Wednesday 15 February 2017 Time: 1:00 pm – 2:00 pm Venue: Manson Lecture Theatre, LSHTM, Keppel Street, London, WC1E 7HT, UK Type of event: Meeting Speakers: Rachel Reeves UCL, Mark Jit, LSHTM, David Hodgson, UCL 13:00 Using electronic health records to evaluate the burden of RSV This talk will present […]

Seminar: Respiratory syncytial virus (RSV) – an epidemiologist’s perspective on vaccine control

  Respiratory syncytial virus (RSV) – an epidemiologist’s perspective on vaccine control Date: Friday 3rd February 2017 Time: 13:00-14:00 Venue: Manson Theatre, Keppel Street  Speaker: Professor James Nokes  James Nokes is Professor of Infectious Disease Epidemiology at the School of Life Sciences, University of Warwick. Since 2001 he has been based full time at the Wellcome […]

Measles and rubella in Europe: a process of elimination

Leading public health experts brought together by the London School of Hygiene and Tropical Medicine and WHO/Europe discuss lessons learnt and the way forward to eliminate measles and rubella in Europe.

Vaccine Centre Scientific Meeting

Vaccine Centre Scientific Meeting Date: Tuesday 24 January 2017 Time: 1:00 pm – 2:00 pm Venue: Manson Lecture Theatre, LSHTM, Keppel Street, London, WC1E 7HT, UK Type of event: Meeting Beyond CRM197: Selection of species specific carrier proteins for pneumococcal conjugate vaccines Presented by Dr Mark Reglinski: UCL Respiratory Medicine Challenges and Opportunities in Vaccine […]

Seminar: Respiratory syncytial virus (RSV) – an epidemiologist’s perspective on vaccine control

  Respiratory syncytial virus (RSV) – an epidemiologist’s perspective on vaccine control Date: Friday 3rd February 2017 Time: 13:00-14:00 Venue: Manson Theatre, Keppel Street Speaker: Professor James Nokes James Nokes is Professor of Infectious Disease Epidemiology at the School of Life Sciences, University of Warwick. Since 2001 he has been based full time at the Wellcome […]

Seminar: Designing attenuated multivalent vaccines for African Horse Sickness virus

Designing attenuated multivalent vaccines for African Horse Sickness virus Hosted by Professor Polly Roy – in the series Pathogen Molecular Biology Department Seminar Date: Thursday 12 January 2017 Time: 12:45 pm – 2:00 pm Venue: Manson Lecture Theatre, LSHTM, Keppel Street, London, WC1E 7HT, UK Type of event: Seminar Speaker: Dr Valeria Lulla, University of […]

Vaccine Centre Scientific Meeting

  Date: Tuesday 24th January 2017 Time: 13:00-14:00 Venue: Manson Theatre, Keppel Street   *** “Beyond CRM197: Selection of species specific carrier proteins for pneumococcal conjugate vaccines” *** Presented by: Dr. Mark Reglinski: UCL Respiratory Medicine *** “Challenges and Opportunities in Vaccine Manufacturing” ***  Presented by: Dr. Tarit Mukhopadhyay: UCL Biochemical engineering   The meeting is […]

Dengue vaccine no silver bullet but worth a shot for those who need it most

Stefan Flasche, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine ‘Dengue fever kills 20 in Burkina Faso’ reports the BBC. ‘Dengue claims 26 lives in Maharashtra’ leads the Times of India. Deaths from dengue are actually rare but these recent headlines are a reminder of the dangers the virus poses and […]

Times Higher Education ‘University of the Year 2016’

The London School of Hygiene & Tropical Medicine were awarded ‘University of the Year 2016’ at last night’s Times Higher Awards. The School was the judges’ unanimous choice for the award, given in recognition of its response to the Ebola epidemic in West Africa in 2014/15. The judges praised the School for putting all of […]

New clues in the fight against tuberculosis

Taane Clark, Professor of Genomics and Global Health at the London School of Hygiene & Tropical Medicine and Dr Ruth McNerney from the University of Cape Town. Have you ever wondered why there is not an effective vaccine against tuberculosis (TB), a disease that kills one and half million people each and every year? Or […]

Got your underwear, bed sheets and vaccination? Why freshers could help eliminate measles

John Edmunds, Professor of Infectious Disease Modelling and Dean of Faculty of Epidemiology & Population It’s the time of year when hundreds of thousands of teenagers are beginning an exciting new chapter in their lives. Freshers’ week will see friendships fostered for life, but for some unfortunate students it will also mean experiencing something not […]

How did England’s national immunisation programme adapt to large scale NHS reforms?

Sandra Mounier-Jack, Senior Lecturer in Health Policy at the London School of Hygiene & Tropical Medicine In April 2013, the National Health Service (NHS) in England was subject to the biggest reorganisation since its creation in 1948. NHS leaders famously described the changes as “so big you could see them from space”. In a very […]

Why can’t we save the world’s babies from sepsis? It’s down to a lack of data

Elizabeth Fitchett, Visiting Research Fellow at the London School of Hygiene & Tropical Medicine and Paediatrics Academic Clinical Fellow at the Institute of Child Health (UCL) Fast-acting, potentially fatal, and ruthlessly unpredictable – every health professional fears sepsis in their patients. Today, 13 September, is World Sepsis Day—a wake-up call to governments and society that the […]

Impact Study of Meningococcal Conjugate Vaccination

The impact of meningococcal conjugate vaccination on pharyngeal carriage of serogroup A meningococci and on transmission of the infection. PI: Brian Greenwood Funders: Wellcome trust and BMGF. The African Meningococcal Carriage Consortium (MenAfriCar) was established in 2009 to determine the pattern of meningococcal carriage across the African meningitis belt before and after the introduction of […]

Trials of New Pneumococcal Vaccines in Gambian Children and Infants

PI: Aderonke Odutola (MRC Unit, The Gambia) Funders: PATH This study is investigating whether addition of two proteins found in all pneumococci (pneumolysin and histidine triad protein)  to the 10-valent pneumococcal conjugate vaccine produced by GlaxoSmithKline (PCV10) can increase the ability of this vaccine to provide protection against pneumococci of serotypes not represented in the vaccine. […]

Pneumococcal Conjugate Vaccine Trial

A phase IV effectiveness study of pneumococcal conjugate vaccine in The Gambia. PI: Grant Mackenzie (MRC Unit, The Gambia) Funding: GAVI, BMGF Following the conduct of a successful trial of a nine-valent pneumococcal conjugate vaccine (PCV) in Upper River region, the Gambian Ministry of Health introduced a seven-valent  pneumococcal conjugate vaccine (PCV7) into the routine […]

Malaria Vaccine Trial

Efficacy of GSK Biologicals’ candidate malaria vaccine (257049)(RTS,S/AS01) against malaria disease caused by P. falciparum in infants and children in Africa. PI: RTS,S Clinical trials partnership (there are no PIs)(LSHTM investigators include Chandramohan Drakeley,  Greenwood, Riley and Schellenberg) Funding: PATH, GSK This phase three trial is being conducted in 11 centres in 7 countries in […]

Typhoid Vaccination in Fiji

PI – Conall Watson Funder – MRC, WHO Western Pacific Region, The Chadwick Trust Indigenous iTaukei Fijians are experiencing a typhoid fever outbreak that began in the mid-2000s, largely affecting young adults in rural areas. LSHTM and partners at the World Health Organization, Australian Aid and international universities are supporting the Ministry of Health to […]

Potential Impact of Future Tuberculosis Vaccines in Setting with High HIV Prevalence and in Aging Populations

PI: Rebecca Harris Funding: MRC and Aeras This research will use models to estimate the epidemiological impact of promising new TB vaccines in high burden settings, with the aim of informing which vaccine candidates and vaccination populations could deliver the greatest public health impact. This will include modelling vaccine impact in settings with high HIV prevalence experiencing […]

WHO Initiative for Vaccine Research/Global Malaria Programme Joint Technical Expert Group

Peter Smith chairs the WHO Initiative for Vaccine Research/Global Malaria programme Joint Technical Expert Group (JTEG) on Malaria Vaccines Entering Pivotal Phase 3 Trials & Beyond which was established in April 2009. JTEG provides advice to WHO on activities related to the development of malaria vaccines at or nearing the pivotal phase 3 trial stage. Stefan […]

Natural Killer cells as effectors of vaccine-induced immunity

PI – Professor Eleanor Riley Funder- Medical Research Council The purpose of this research programme is to evaluate the predictive potential of two new potential correlates of protection (the identification of immune responses which, when present, are a good indicator that the person is protected), namely the ability of immune cells called T cells and NK […]

The Vaccine Confidence Project

Monitoring public confidence in immunisation programmes PI: Heidi Larson Funding: Innovative Medicines Initiative (IMI), National Institute for Health Research, the World Health Organization, the Bill & Melinda Gates Foundation, Novartis, Center for Strategic & International Studies (CSIS), Pharmaceutical Research and Manufacturers of America (PhRMA). Partners: Public Health England, HealthMap, ProMED, Imperial College London, Brighton collaboration, Chatham House, The Inclen […]

PATH SPN Whole Cell Vaccine

Funding: PATH Vaccine Solutions Anthony Scott works with the Clinical Development team (Scientific Lead: Dr Cheryl Keech) at PATH, Seattle, to advance a third-generation pneumococcal vaccine. The cost of developing and manufacturing pneumococcal conjugate vaccines (PCV), and the limited serotype coverage of current PCVs suggests the need for a vaccine that is effective against the […]

Pneumococcal Conjugate Vaccine Impact Study

PI: Anthony Scott Funding: Wellcome Trust and GAVI Alliance Using a passive-surveillance system established in 2003 at the Kilifi Health and Demographic Surveillance System, in Kilifi, Kenya, this project is a Phase IV, before-after study, examining the population impact of the 10-valent Pneumococcal Conjugate Vaccine (PCV), which was introduced into the Kenyan childhood immunization system […]

The NIHR Health Protection Research Unit in Immunisation at LSHTM

The NIHR Health Protection Research Unit in Immunisation at LSHTM PI: Anthony Scott (LSHTM) and Mary Ramsay (PHE) Funding: National Institute for Health Research This is one of 13 Health Protection Research Units (HPRU) funded by NIHR to foster collaboration between English Universities and Public Health England. The 5-year project aims to undertake research to […]

Workshop of Evaluation of Vaccine for Public Health

PI: Laura Rodrigues and Eliseu Waldman Funder: FAPESP (submitted for funding) A 3 day workshop for early career scientists between LSHTM and other UK institutions and USP and other Brazilian institutions to share research experiences and explore collaborations.

Evaluation of an E-health Vaccine System: The Juarez System in the City of Araraquara, Brazil

PI: Ana Paula Sato; Co-PIs: Eliseu Waldman, Laura Cunha Rodrigues and Edmar Martineli Funder: FAPESP (submitted) Introduction: Electronic systems with information about vaccinations with individual records are in the process of being developed in Brazil as tools for scheduling vaccinations, recall and monitoring of vaccination coverage as well as a research tool. Objectives: To evaluate […]

Pertussis Vaccination During Pregency and Reduction in Incidence in Children Under 1 in Brazil

PI: Paulo Batista Funder: CNPq –Brazil Petussis vaccine was introduced to pregnant women in 2013 to prevent pertussis in children to you young  to have received compete vaccination and to contribute to the reduction  the incidence in infants in general.. This project  evaluates the efficacy of vaccination by comparing incidence of pertussis in children born to vaccinated […]

Rotavirus Vaccine

PI: Mauricio BArreto,ISC, Brazil and Yuri Travassos, PhD student Funded: Brazilian MRC A case control study of rotavirus vaccine efficacy, conducted in 4 regions in Brazil, where cases are hospitalized cases of diarrhoea with confirmed rota is stools and controls are children hospitalized with for other non vaccine related conditions; diarrhoea without rotavirus were also ascertained to […]

BCG Revaccination Trial

PI : Laura Cunha Rodrigues and Mauricio Barreto Funders: DFID, Brazilian Minister of Health A cluster-randomized trial involving more than 200 000 school-aged children from Salvador and Manaus (BCG-REVACC) followed for over 20 years. The trial tested BCG-VE of a second BCG dose against tuberculosis and against leprosy when administered at school age. The trial […]

Observational Study to Estimate the Changes in the Efficacy of BCG with Time Since Vaccination

PI: Laura Rodrigues, Punam Mangtani, Ibrahim Abubakar Funder: NIHR BCG vaccination until 2005, was given mostly at school children; since then it is given to infants if required. We know that BCG is a relatively good vaccination when given at school-age, but we do not know the exact protection. We do not know if any […]

Production of Inexpensive Recombinant Glycoconjugate Vaccines

PI – Professor Brendan Wren 
Funders- Medical Research Council, Biotechnology and Biological Sciences Research Council, Defence Science and Technology Laboratory, The Gates Foundation The most successful human vaccines are often glycoconjugate as the combination of a protein coupled to a glycan induces both a T-cell dependent and independent immune response evoking a protective and lasting […]

ProVac Initiative

Support for national policy choices about new vaccines in low and middle income countries PI: Andy Clark Funding: BMGF (via PAHO) ProVac (promotion of evidence-based decision making for the introduction of new vaccines)started as an initiative in the Americas region of WHO to strengthen national capacity to conduct economic evaluations of new vaccines. An important part […]

Vaccine Schedules Initiative

Support for global and national policy choices about vaccine schedules in low and middle income countries. PI: Colin Sanderson Funding: BMGF (via WHO) The WHO Initiative for Vaccine Research (IVR) has commissioned researchers from the Vaccine Centre (Andy Clark and Colin Sanderson) to evaluate the balance between benefit and risk for rotavirus vaccination, and the impact […]

Supporting cost-effectiveness evaluations of human papillomavirus in low and middle income countries

PI: Mark Jit Funding: WHO WHO recommends that cost-effectiveness is considered before human papillomavirus (HPV) vaccination is introduced into national schedules. However, resources for cost-effectiveness evaluations are often limited in many low and middle income countries. This project aims to understand current cost-effectiveness evidence behind HPV vaccination options in such countries, to compare existing economic […]

Assessing the broader economic impact of vaccines and immunisation programmes

PI: Mark Jit Funding: WHO Economic evaluations of immunisation programmes usually focus on the morbidity and mortality prevented by the vaccine together with its economic impact on the health care sector. More recently, greater attention has been paid to the economic impact of vaccines on broader measures, such as cognitive and educational outcomes, household decision-making, […]

Evaluating the health and economic impact of a risk group based strategy for seasonal influenza in low and middle income countries (LMICs)

PI: Mark Jit Funding: WHO The World Health Organization’s expert committee on vaccination (SAGE) has recommended introducing seasonal influenza vaccination for pregnant women, then for health care workers, people in clinical risk groups, the elderly and children. However, economic evidence to support such introduction decisions is scarce in low and middle income countries. This project […]

Costs of introducing pneumococcal, rotavirus and a second dose of measles vaccine into the Zambian routine immunisation schedule: Are expansions sustainable?

PI: Ulla Griffiths Funding: Bill and Melinda Gates Foundation through Center for Infectious Disease Research in Zambia (CIDRZ) Introductions of new vaccines in low-income countries have accelerated since the GAVI Alliance was established in 2000. In this study the economic costs and the sustainability of introducing pneumococcal conjugate vaccine (PCV), rotavirus vaccine and a second […]

Evaluation of costs and performance of meningitis surveillance in Chad

PI: Ulla Griffiths Funding: Bill and Melinda Gates Foundation through Agence de Médecine Préventive Chad, like other countries in the African meningitis-belt region, has historically been ravaged by recurring meningitis outbreaks, mainly caused by serogroup A Neisseria (NmA).  A new conjugate vaccine (MenAfriVac®) developed to combat this strain has shown to be effective in decreasing […]

PhD Student Presentation Event

  The Vaccine Centre hosted its first PhD student presentation event on Friday 5th December. The event brought together PhD students, supervisors and members of faculty to discuss the presenters PhD projects and a variety of issues, both academic and practical that students face during their PhDs. The presentations stoked engaging debates and we are looking forward to […]

Anthony Scott speaks at Parliamentary Event

Anthony Scott, Vaccine Centre Director, was invited by the charity Save The Children to respond to their report on the importance of the work of  GAVI, The Vaccine Alliance’s future work. GAVI is currently preparing for a replenishment meeting in January 2015, aiming to raise $7.5 billion in order to deliver its 2016-2020 strategy. Its strategy […]

10/06/15 – 25/09/15 | Vaccination: past, present and future: An Exhibition | Keppel Street foyer

  The Vaccine Centre, in collaboration with The Centre for Public Health History at LSHTM, curated an exhibition entitled ‘Vaccinations: past, present and future’ in the foyer of the Keppel street building. This exhibition explores the history of vaccination, some of the current challenges we face, and how we continue to research vaccine-preventable disease and […]

HPRU in Immunisation hold Scientific Meeting

The Health Protection Research Unit (HPRU) in Immunisation held a Scientific Meeting on 30th March, 2015, at the London School of Hygiene and Tropical Medicine (LSHTM)to conclude the first year of its NIHR funding. Peter Piot, Director, LSHTM, gave an introductory speech and then opened the floor to HPRU scientists to present the scientific progress […]

Request for proposal: 5th Asian Vaccine Conference

Type: Proposal Organiser: ASVAC Area(s): New vaccine recommendations > More> Deadline: 03/02/15   The Scientific Committee invites all interested individuals to submit abstracts for the 5th Asian Vaccine Conference (ASVAC 2015). You may now submit your abstract by clicking the button above. Accepted abstracts will be selected for poster presentations only and will be published in the […]

Mini-symposium on Decision Support Models in Vaccine Development, Implementation and Policy

The Vaccine Centre hosted a mini-symposium on decision support models in vaccine development, implementation and policy. Academics involved in the development of different models had the opportunity to present their work and discuss it with others involved in the field. Presentations included the following: Andy Clark, LSHTM – Models used to support vaccine decisions in low and […]

Comparison of two dose and three dose human papillomavirus vaccine schedules

Comparison of two dose and three dose human papillomavirus vaccine schedules: cost effectiveness analysis based on transmission model Mark Jit, Marc Brisson, Jean-François Laprise, Yoon Hong Choi. Read more about this publication on the LSHTM website: http://blogs.lshtm.ac.uk/news/2015/01/09/switch-two-dose-hpv-vaccine-schedule-cost-effective/ Read the paper

Vaccine Centre Scientific Meeting

Airport screening for Ebola

The British Medical Journal Editorial for the BMJ addressing the implemention of Ebol screening at Heathrow and Gatwick airports and Eurostar terminals. Prof. David Mabey, Dr Stefan Flasch, Prof W John Edmunds   For full article follow this link > http://dx.doi.org/10.1136/bmj.g6202

Population effect of 10-valent pneumococcal conjugate vaccine

The Lancet Global Health Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi , Kenya: findings from cross-sectional carriage studies Laura L Hammitt, Donald O Akech, Susan C Morpeth, Angela Karani, Norbert Kihuha, Sammy Nyongesa, Tahreni Bwanaali, Edward Mumbo, Tatu Kamau, Shahnaaz K Sharif, J […]

2014 Vaccine Short Course

The London School of Hygiene and Tropical Medicine, in association with the Vaccine Centre, runs an annual Vaccine short course entitled:  ‘Epidemiological evaluation of vaccines: efficacy, safety and policy’. This year the course will be running from 7 – 18 July, based at the Keppel Street building, Bloomsbury, and places are still available! The Vaccines short […]

Vaccine Centre members teach at the International Vaccine Institute, Seoul

  Hazel Dockrell and Pauline Paterson taught on the 14th Advanced Vaccinology Course held at the International Vaccine Institute in Seoul from Mar 12-16th, 2014; Hazel talked on Basic immunology and biomarkers and Pauline gave a lecture on Confidence in vaccines: ethical, cultural and political issues affecting vaccine acceptance. The course was attended by 71 […]

Leishmania Vaccine

Science Transnational Medicine  Modular Multiantigen T Cell Epitope–Enriched DNA Vaccine Against Human Leishmaniasis Shantanabha Das, Anja Freier, Thouraya Boussoffara, Sushmita Das, Detlef Oswald, Florian O. Losch, Melanie Selka, Nina Sacerdoti-Sierra, Gabriele Schönian, Karl-Heinz Wiesmüller, Karin Seifert, Matthias Schroff, Christiane Juhls, Charles L. Jaffe, Syamal Roy, Pradeep Das, Hechmi Louzir, Simon L. Croft, Farrokh Modabber and Peter Walden.   Abstract The leishmaniases are protozoal diseases that severely affect large populations in tropical and subtropical regions. There […]

Vaccine Centre members teach at the International Vaccine Institute, Seoul

Hazel Dockrell and Pauline Paterson taught on the 14th Advanced Vaccinology Course held at the International Vaccine Institute in Seoul from Mar 12-16th, 2014; Hazel talked on Basic immunology and biomarkers and Pauline gave a lecture on Confidence in vaccines: ethical, cultural and political issues affecting vaccine acceptance. The course was attended by 71 individuals […]

New Book from Vaccine Centre researcher Tracey Chantler: "Global Health Research in an Unequal World: Ethics Case Studies from Africa"

This book is a collection of fictionalised case studies of everyday ethical dilemmas and challenges, encountered in the process of conducting global health research in places where the effects of global, political and economic inequality are particularly evident. It is a training tool to fill the gap between research ethics guidelines, and their implementation 'on the ground'. The case studies, therefore, focus on 'relational' ethics: ethical actions and ideas that emerge through relations with others, rather than in regulations.

Got your underwear, bed sheets and vaccination? Why freshers could help eliminate measles (Prof John Edmunds)

It’s the time of year when hundreds of thousands of teenagers are beginning an exciting new chapter in their lives. Freshers’ week will see friendships fostered for life, but for some unfortunate students it will also mean experiencing something not quite as welcome. Close contact between large groups of young adults is the perfect breeding ground for infectious disease. Perhaps surprisingly, measles is one of them.