Population effect of 10-valent pneumococcal conjugate vaccine

The Lancet Global Health

Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi , Kenya: findings from cross-sectional carriage studies

Laura L Hammitt, Donald O Akech, Susan C Morpeth, Angela Karani, Norbert Kihuha, Sammy Nyongesa, Tahreni Bwanaali, Edward Mumbo, Tatu Kamau, Shahnaaz K Sharif, J Anthony G Scott



Background The effect of 7-valent pneumococcal conjugate vaccine (PCV) in developed countries was enhanced by indirect protection of unvaccinated individuals, mediated by reduced nasopharyngeal carriage of vaccine-serotype pneumococci. The potential indirect protection of 10-valent PCV (PCV10) in a developing country setting is unknown. We sought to estimate the effectiveness of introduction of PCV10 in Kenya against carriage of vaccine serotypes and its effect on other bacteria.

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